WebSimilarly, PML depletion suppressed POT1 poly-ubiquitination, suggesting an interplay between USP7 and PML to trigger POT1 degradation in TSPYL5-depleted ALT + cells. We demonstrate that ALT telomeres need to be protected from POT1 degradation in ALT-associated PML bodies and identify TSPYL5 as an ALT + cancer-specific therapeutic target. WebMar 21, 2024 · Biorbyt antibodies for TSPYL5. orb1268896. orb1291635. Boster Bio Antibodies for TSPYL5. A10648-2. Boster Bio Custom Antibody Services (starting from …
Expression of TSPYL5 in cancer - Summary - Protein Atlas
WebExpression of TSPYL5 (KIAA1750) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. WebJul 15, 2024 · Further, inhibition of STAT3 (Y705) led to decreased GR and TSPYL5, suggesting that MUC16 regulates TSPYL5 through the JAK2/STAT3/GR axis. Also, MUC16 … fairfield council kerbside cleanup
Alternative Lengthening of Telomeres: Building Bridges To …
WebAbout 0:00 on April 12, 2013, after the police determined that Lin was a suspect and summoned him, Lin then confessed that he had put N-nitrosodimethylamine in dorm ... WebSummary of TSPYL5 expression in human tissue. Cytoplasmic expression in several tissues with highest levels in spermatogonia of testis. WebAlternative lengthening of telomeres (ALT) is a mechanism of telomere maintenance that is observed in many of the most recalcitrant cancer subtypes. Telomeres in ALT cancer cells exhibit a distinctive nucleoprotein architecture shaped by the mismanagement of chromatin that fosters cycles of DNA damage and replicative stress that activate homology-directed … dog training in ann arbor