WebSep 1, 2024 · To this end we coupled GST-FIP200 to beads and added mCherry-p62 or mCherry-TAX1BP1 (Fig. 5a and Supplementary Fig. 5a). p62 detectably bound to FIP200 … WebDownload scientific diagram Aberrant TBK1 accumulation depends on TAX1BP1. (A) fip200 KO, FIP200 WT, and FIP200 ΔCT MEFs were transfected with either 20 nM …
Aberrant TBK1 accumulation depends on TAX1BP1. (A) fip200 KO, …
WebSep 8, 2024 · TAX1BP1's ability to cluster FIP200 around NBR1 cargo and induce local autophagosome formation enforces cargo specificity and replaces the requirement for … WebIt is hypothesized that FIP200 ensures the inducible activation of TBK1 at SQSTM1/p62 condensates, a component of the autophagy-inducing ULK1 complex, is not present or … does peyton manning have a sister
FIP200 controls the TBK1 activation threshold at SQSTM1/p62 …
WebApr 9, 2024 · VCP/p97 modulates PtdIns3P production and autophagy initiation. Spatiotemporal Control of ULK1 by NDP52 and TBK1 during selective autophagy. TNIP1 … Web#bioart分享# ——【Mol Cell丨TNIP1:线粒体自噬的“安全检查员”】 2024年3月9日,来自美国国立卫生研究院的Richard J. Youle团队在#Molecular Cell#在线发表题为 #TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1# 的文章,发现TNIP1通过与TAX1BP1和FIP200以竞争性方式结合而发挥了线粒体自噬 ... WebSep 5, 2024 · TAX1BP1 binds directly to NCOA4 and is required for lysosomal trafficking of ferritin under basal and iron-depleted conditions. Under basal conditions ULK1/2-FIP200 … does peyton lose the baby