WebApr 3, 2024 · It has recently been discovered that the E3 ubiquitin ligase STIP1 homology and U-box–containing protein 1 (STUB1 or CHIP) is up-regulated during the senescence of human fibroblasts and modulates cell senescence. However, the molecular mechanism underlying STUB1-controlled senescence is not clear. WebApr 3, 2024 · It has recently been discovered that the E3 ubiquitin ligase STIP1 homology and U-box–containing protein 1 (STUB1 or CHIP) is up-regulated during the senescence …
STUB1 is an intracellular checkpoint for interferon …
The CHIP protein encoded by this gene binds to and inhibits the ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the forward reaction of the HSC70-HSP70 substrate-binding cycle. In addition, CHIP possesses E3 ubiquitin ligase activity and promotes ubiquitylation, mainly of chaperone-bound misfolded proteins. CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the st… WebMar 26, 2024 · CHIP/STUB1 Antibody (C-10) is an IgG 1 κ mouse monoclonal CHIP antibody that detects CHIP of mouse, rat and human origin by WB, IP, IF and ELISA. CHIP/STUB1 … pick for a pendant
CHIP/STUB1 Antibody (C-10) SCBT - Santa Cruz Biotechnology
WebSTUB1. TFEB (Transcription Factor EB) is a master regulator of autophagosome, lysosome, and mitochondrial biogenesis. Phosphorylation of TFEB by mammalian target of … WebJun 7, 2024 · Stub1 (STIP1 homology and U-box containing protein 1), or CHIP (C terminus of HSC70-interacting protein) ( Paul and Ghosh, 2014 ; Wang et al., 2024 ), is an E3 Ub ligase comprising two domains, a tetratricopeptide repeats (TPRs) associated with protein-protein interactions, and a U-box domain that confers E3 ligase activity ( Paul and Ghosh, 2014 Web2 days ago · Recently, our studies have shown that YOD1 is a DUB that helps to stabilize PML/RARα, and that the compound ubiquitin isopeptidase inhibitor I (G5) degrades both PML/RARα and its drug-resistant mutant forms by inhibiting the ubiquitination of YOD1, finally eliminating APL cells in vivo and in vitro. 5 Interestingly, suppression of YOD1 … pick foods low on the glycemic index