Lineage infidelity
NettetA significant trend was observed relating the presence of lineage infidelity and failure of remission-induction. The data are interpreted as support for abnormal gene expression … Nettet4. jul. 2013 · Lineage infidelity correlated with failure of remission and was attributed to abnormal gene expression. Lineage promiscuity. Transient bi- or multiphenotypic stem cell stages that are preserved as a relic in leukaemic blast populations due to the primary oncogenic event that is involved in maturation arrest (Greaves et al, 1986).
Lineage infidelity
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Nettet4. mai 2024 · Investigating mechanism, we discover that irrespective of cellular origin, lineage infidelity occurs in wounding when stress-responsive enhancers become activated and override homeostatic enhancers that govern lineage specificity. In cancer, stress-responsive transcription factor levels rise, causing lineage commanders to reach … Nettet4. mai 2024 · Wound and Tumor Converge on Lineage Infidelity Irrespective of Stem Cell Origin. Regardless of SC origin, lineage infidelity surfaced in HFSCs and in EpdSCs in response to injury. In full-thickness wounds, mobilized EpdSCs at wound edges induced HFSC identity TFs SOX9 and TCF3, before resolving back to EpdSC.
NettetAccount sharing is a violation of the Lineage II User Agreement and an account can be closed for it if it’s found to have been shared. Not every violation of the rules will lead to … Nettet(8) This finding supports the concept of lineage fidelity, and suggests that true interlineage infidelity, myeloid to lymphoid, is a rare occurrence in adult acute nonlymphocytic leukemia. (9) In recent weeks Trump has been cranking up his gender attacks on Clinton, accusing her of playing the woman card and criticising her for being an “enabler” of her …
NettetThe transition from an epithelial to a melanocytic phenotype (lineage infidelity) appears to occur much more frequently than previously assumed and occurs in restricted areas of … NettetAdditionally, the biological mechanisms underlying lineage infidelity are poorly understood. Here we seek to establish more precise biological characterization of this …
NettetThe AR+ lineage-infidelity state is a plastic intermediate. Persistent AR expression in the lineage-infidelity state raises potential therapeutic implications for restoring canonical …
Nettet22. sep. 2024 · Therapeutic resistance in prostate cancer can be driven by lineage plasticity, but the mechanisms behind this are unclear, and therapies to prevent or reverse the process are nonexistent. A new... chicken piccata with capers giadahttp://yejinggelab.com/research/ chicken piccata with capers wine pairingNettetIntramyeloid lineage infidelity was considered to exist when individual cells contained markers of more than one of the three myeloid lineages: granulopoiesis, erythropoiesis, … chicken piccata with capers sauceNettetStem cell lineage infidelity occurs transiently in wounds and persists in cancer • Wounds and cancer converge on lineage infidelity irrespective of stem cell origin • Lineage … chicken piccata with capers and wine sauceNettet24. okt. 2024 · Statement of significance Infrequently mutated genes comprise most of the mutational burden in breast tumors but are poorly understood.In-vivo CRISPR screening identified functional tumor suppressors that converged on epigenetic regulation. Loss of epigenetic regulators accelerated tumorigenesis and revealed lineage infidelity and … chicken picking exercisesNettet2. des. 2024 · In pancreatic ductal adenocarcinoma (PDAC), the role of lineage infidelity and phenotype switching is still unclear. Two consensus molecular subtypes of PDAC have been proposed that mainly reflect the existence of cell lineages with different degrees of fidelity to pancreatic endodermal precursors. chicken piccata with capers and mushroomsNettetSingle-cell RNA sequencing of cutaneous ILC-enriched cell samples confirmed the predominance of biologically heterogeneous group 2 ILCs and, for the first time, … chicken piccata with orzo