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Golph3 autophagy

WebMay 15, 2024 · In this study, we demonstrated that Golgi phosphorylation protein 3 (GOLPH3), a highly conserved protein basically concentrates in the trans-Golgi network, promoted glioma autophagy. Inhibiting autophagy by using chloroquine suppressed the stimulating effect of GOLPH3 on glioma malignant development both in vitro and in vivo. WebApr 12, 2024 · GOLPH3 was confirmed as the downstream target of miR-577. miR-577 contained the binding site for the 3′-UTR of GOLPH3, negatively controlled its expression and further inhibited translation of the protein . ... M.J.; Liu, Z.; Dong, Z. Autophagy in kidney homeostasis and disease. Nat. Rev. Nephrol. 2024, 16, 489–508.

GOLPH3 protein controls organ growth by interacting …

WebIn this study, we have shown the transcriptional regulation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) induced by retinoic acid (RA), a potent neuronal cell regulator in glioblastoma cell line (U-87MG). WebJan 7, 2014 · GOLPH3 is a PI4P-binding protein that depends on PI4P for its Golgi localization [ 20 ]. The GOLPH3-interacting protein MYO18A localizes to the cell cortex in addition to the Golgi. Tan et al. raised the possibility that GOLPH3 and MYO18A have additional roles outside of the Golgi [ 91 ]. installing gaming services windows 11 https://lgfcomunication.com

Study of GOLPH3: a Potential Stress-Inducible Protein from

WebMay 31, 2024 · Rahman et al. create Atg8a-LDS (LIR motif docking site) mutants in Drosophila. They show that Atg8a-LDS mutants accumulate autophagy substrates and have reduced lifespan. Using quantitative proteomics, they identify Golgi protein GMAP as a LIR motif-containing protein that interacts with Atg8a. They show that GMAP LIR mutants … WebJul 15, 2024 · This study unveiled a new selective autophagy of the Golgi apparatus (Golgiphagy). In addition, GOLPH3 might act as a novel cargo receptor to regulate … WebNov 13, 2024 · GOLPH3 is stimulated by oxidative stress and is involved in signal transduction , while GOLPH3 silencing contributed towards alleviating GA stress … jiffy lube wheeling il

STK25-induced inhibition of aerobic glycolysis via GOLPH3 …

Category:GOLPH3 promotes glioma progression by enhancing PHB2-mediated autophagy ...

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Golph3 autophagy

Golgi phosphoprotein 3 induces autophagy and epithelial ... - Nat…

WebApr 1, 2024 · Significance This study unveiled a new selective autophagy of the Golgi apparatus (Golgiphagy). In addition, GOLPH3 might act as a novel cargo receptor to regulate Golgiphagy. Maintaining...

Golph3 autophagy

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WebJul 11, 2024 · The primary antibodies were used at the following dilutions: STK25 (1:1000, Cat #25821–1-AP, Proteintech), GOLPH3 (1:1000, Cat #19112–1-AP, Proteintech), PDHK1 (1:1000, Cat #3820, Cell Signaling Technology), HK2 (1:1000, Cat #2867, Cell Signaling Technology), LDHA (1:1000, Cat #2012, Cell Signaling Technology), AKT (1:1000, Cat … WebMar 20, 2024 · Previous studies speculated that Golgi phosphoprotein 3 (GOLPH3) may have a regulatory role in the process of endometrial decidualization, while the specific molecular mechanisms of GOLPH3 is unclear.

WebCD51 + CD61 (Integrin alpha V + Integrin beta 3) CD51 / Integrin alpha V. CD52 WebDec 1, 2024 · GOLPH3 contributed to the development of lung diseases. Through changes in GOLPH3 levels and abnormal autophagy in lung epithelial cells, cigarette smoke condensate treatment might disturb endoplasmic reticulum-Golgi network homeostasis and increase ROS generation ( Yu et al., 2016 ).

WebJul 15, 2024 · However, knocking down GOLPH3 inhibited the Golgiphagy. Significance This study unveiled a new selective autophagy of the Golgi apparatus (Golgiphagy). In addition, GOLPH3 might act as a novel cargo receptor to regulate Golgiphagy. Maintaining homeostasis of the Golgi apparatus via GOLPH3-mediated autophagy was … WebAutophagy: Recycles damaged cell parts into fully functioning cell parts. Gets rid of nonfunctional cell parts that take up space and slow performance. Destroys pathogens in a cell that can damage it, like viruses and bacteria. Autophagy plays an important role when it comes to aging and longevity, too.

WebOur results suggest that high levels of CENPH impaired CRC malignant phenotypes and rapamycin sensitivity through cooperating with GOLPH3 on the modulation of mTOR signaling pathway. Taken together, these findings indicate that CENPH may become a valuable predictor for rapamycin sensitivity. Materials and Methods Ethics statement

WebMay 15, 2024 · In this study, we demonstrated that Golgi phosphorylation protein 3 (GOLPH3), a highly conserved protein basically concentrates in the trans-Golgi … jiffy lube wilmington ncWebMay 15, 2024 · In this study, we demonstrated that Golgi phosphorylation protein 3 (GOLPH3), a highly conserved protein basically concentrates in the trans-Golgi network, … installing garage door lift cablesWeb目的:探讨细胞周期调控因子c-abl、CDK2在新疆哈萨克族食管鳞癌发生发展中的作用.方法:采用逆转录PCR方法在48例新疆哈萨克族食管鳞癌组织及远端无癌组织中检测c-abl、CDK2的表达.结果:在新疆哈萨克族食管鳞癌中:(1)c-abl和CDK2在癌组织与癌旁组织中的阳性表达率比较,差异均无统计学意义(P>0.05).(2)在癌 ... jiffy lube what do they doWebJun 1, 2024 · As an example of its role in Golgi protein sorting, Golgi phosphoprotein 3 (GOLPH3) is able to bind PI (4)P at the trans-Golgi and simultaneously interact with mislocalized Golgi membrane proteins and COPI to sort them for retrograde recycling [17 ]. installing garage ceiling rackWeb开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 installing garage ceiling mounted heaterWebNational Center for Biotechnology Information jiffy lube wilmington maWebFeb 21, 2024 · In this study, we aimed to investigate whether and how Golgi phosphoprotein 3 (GOLPH3) facilitates colon cancer metastasis via the regulation of … jiffy lube windshield repair cost